Ultrasound measurement of change in kidney volume is a sensitive indicator of severity of renal parenchymal injury
| Autor: | Paul M. O'Connor, Bansari Patel, Sarah C. Ray, Qingqing Wei, Jingping Sun, G. Ryan Crislip, Aaron J. Polichnowski, Jennifer C. Sullivan, Riyaz Mohamed |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Pathology medicine.medical_specialty Physiology Stereology Kidney Volume Kidney Rats Sprague-Dawley Rats Inbred SHR Edema Parenchyma medicine Animals Pathological Acute tubular necrosis Ultrasonography business.industry Ultrasound Acute kidney injury Acute Kidney Injury medicine.disease Rats Reperfusion Injury Female medicine.symptom business Research Article |
| Zdroj: | Am J Physiol Renal Physiol |
| ISSN: | 1522-1466 1931-857X |
| DOI: | 10.1152/ajprenal.00221.2020 |
| Popis: | Noninvasive determination of the severity of parenchymal injury in acute kidney injury remains challenging. Edema is an early pathological process following injury, which may correlate with changes in kidney volume. The goal of the present study was to test the hypothesis that “increases in kidney volume measured in vivo using ultrasound correlate with the degree of renal parenchymal injury.” Ischemia-reperfusion (IR) of varying length was used to produce graded tissue injury. We first determined 1) whether regional kidney volume in rats varied with the severity (0, 15, 30, and 45 min) of warm bilateral IR and 2) whether this correlated with tubular injury score. We then determined whether these changes could be measured in vivo using three-dimensional ultrasound. Finally, we evaluated cumulative changes in kidney volume up to 14 days post-IR in rats to determine whether changes in renal volume were predictive of latent tubular injury following recovery of filtration. Experiments concluded that noninvasive ultrasound measurements of change in kidney volume over 2 wk are predictive of tubular injury following IR even in animals in which plasma creatinine was not elevated. We conclude that ultrasound measurements of volume are a sensitive, noninvasive marker of tissue injury in rats and that the use of three-dimensional ultrasound measurements may provide useful information regarding the timing, severity, and recovery from renal tissue injury in experimental studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|