Irisin as a Novel Biomarker of Subclinical Atherosclerosis in Severe Obesity
| Autor: | Júlia Carmona-Maurici, Araceli Rosa, Natalia Azcona-Granada, Elionora Peña, David Ricart-Jané, Anna Viñas, Maria Dolores López-Tejero, Joan Carles Domingo, Antonio Miñarro, Juan Antonio Baena-Fustegueras, Julia Peinado-Onsurbe, Eva Pardina |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
Trastorns del metabolisme
Organic Chemistry Obesitat mòrbida irisin severe obesity metabolic disorders subclinical atherosclerosis bariatric surgery FNDC5 gene rs3480 genetic variability General Medicine Atherosclerosis Catalysis Computer Science Applications Inorganic Chemistry Morbid obesity Disorders of metabolism Physical and Theoretical Chemistry Molecular Biology Spectroscopy Aterosclerosi |
| Zdroj: | International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8171 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms24098171 |
| Popis: | Severe obesity (SO) can accelerate atherosclerosis and the onset of acute cardiovascular events. The diagnosis of atherosclerosis in the context of a high body mass index (BMI) can be challenging, making the identification of biomarkers clinically relevant. We aimed to assess the usefulness of irisin as a biomarker for subclinical atherosclerosis in participants with SO. This prospective observational study included 61 participants undergoing bariatric surgery for SO, defined as a BMI >40 kg/m2 or >35 kg/m2 with at least one comorbidity. Atherosclerotic plaques were detected by ultrasound. Plasma samples were obtained 1 month before and at 6 and 12 months after bariatric surgery to measure irisin by ELISA. Additionally, subcutaneous samples of adipose tissue were taken and genotyped to identify irisin polymorphism rs3480. Irisin levels were positively correlated with BMI (r = 0.23, p = 0.0064), negatively correlated with atheroma-related parameters (e.g., carotid intima-media thickness), and lower in subjects with atheroma (p < 0.0002). Irisin also showed good overall accuracy for discriminating plaque presence (AUC, 0.81; 95% CI, 0.6956–0.9156). However, the rs3480 polymorphism correlated with neither the irisin levels nor the presence of atheromas. Iirisin could identify subclinical atherosclerosis in SO and might facilitate clinical diagnosis. |
| Databáze: | OpenAIRE |
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