Congenital Melanoma: A Case Suggesting Rhabdomyogenic Differentiation
| Autor: | M Murakami, T Koyama, O Nishihara, T Masuda |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms Dermatology Antigen Antigens Neoplasm Congenital melanocytic nevus Humans Medicine Melanoma business.industry Infant Newborn Melanocytic nevus medicine.disease Immunohistochemistry Neoplasm Proteins medicine.anatomical_structure Scalp Dermatoses Pediatrics Perinatology and Child Health Female Desmin Basal lamina business Melanoma-Specific Antigens Epithelioid cell |
| Zdroj: | Pediatric Dermatology. 13:389-393 |
| ISSN: | 1525-1470 0736-8046 |
| DOI: | 10.1111/j.1525-1470.1996.tb00707.x |
| Popis: | A newborn girl had some subcutaneous masses within a giant congenital melanocytic nevus in the left parietal area. Microscopic examination revealed melanoma. The tumor consisted of two different patterns, being composed partly of epithelioid cells and partly of spindle-shaped cells. Immunohistochemically the epithelioid cells showed a positive reaction for HMB-45 and NKI/C3, and a negative reaction for desmin and alpha-sarcomeric actin. The spindle-shaped cells showed a negative reaction for HMB-45 and NKI/C3, and a positive reaction for desmin and alpha-sarcomeric actin. Ultrastructurally the spindle-shaped cells had some schwannian features, namely, a basal lamina, interdigitating cell processes, and junctional complexes. The pathologic findings of our case suggest possible direct rhabdomyogenic differentiation of melanoma cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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