Prognostic Impact of Loop Diuretics in Patients With Chronic Heart Failure – Effects of Addition of Renin-Angiotensin-Aldosterone System Inhibitors and β-Blockers –
| Autor: | Masanobu Miura, Satoshi Miyata, Ruri Abe, Yasuhiko Sakata, Shintaro Kasahara, Takeo Onose, Hiroaki Shimokawa, Takeshi Yamauchi, Koichiro Sugimura, Soichiro Tadaki, Kanako Tsuji, Kotaro Nochioka, Takuya Oikawa, Jun Takahashi |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Adrenergic beta-Antagonists 030204 cardiovascular system & hematology Renin-Angiotensin System 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Mineralocorticoid receptor Internal medicine Renin–angiotensin system medicine Humans 030212 general & internal medicine Myocardial infarction Diuretics Stroke Aged Mineralocorticoid Receptor Antagonists Proportional Hazards Models Heart Failure Aldosterone Dose-Response Relationship Drug business.industry Proportional hazards model Hazard ratio General Medicine Prognosis medicine.disease Endocrinology chemistry Heart failure Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation Journal. 80:1396-1403 |
| ISSN: | 1347-4820 1346-9843 1396-1403 |
| DOI: | 10.1253/circj.cj-16-0216 |
| Popis: | BACKGROUND It remains to be elucidated whether addition of renin-angiotensin-aldosterone system (RAAS) inhibitors and/or β-blockers to loop diuretics has a beneficial prognostic impact on chronic heart failure (CHF) patients. METHODS AND RESULTS From the Chronic Heart failure Analysis and Registry in the Tohoku district 2 (CHART-2) Study (n=10,219), we enrolled 4,134 consecutive patients with symptomatic stage C/D CHF (mean age, 69.3 years, 67.7% male). We constructed Cox models for composite of death, myocardial infarction, stroke and HF admission. On multivariate inverse probability of treatment weighted (IPTW) Cox modeling, loop diuretics use was associated with worse prognosis with hazard ratio (HR) 1.28 (P |
| Databáze: | OpenAIRE |
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