Effect of gene-environment interaction (arsenic exposure - PON1 Q192R polymorphism) on cardiovascular disease biomarkers in Mexican population

Autor:	José A. Varela-Silva, Yesenia Araiza-Gamboa, Leticia Carrizales-Yáñez, Iván N. Pérez-Maldonado, Ángeles C. Ochoa-Martínez, Sandra T. Orta-García
Rok vydání:	2020
Předmět:	Adult Genotype Health Toxicology and Mutagenesis Urinary system Physiology 010501 environmental sciences Toxicology Fatty Acid-Binding Proteins 01 natural sciences Arsenic 03 medical and health sciences chemistry.chemical_compound Young Adult Medicine Humans Gene–environment interaction Allele Allele frequency Mexico Alleles 030304 developmental biology 0105 earth and related environmental sciences Cause of death Aged Pharmacology 0303 health sciences Creatinine Polymorphism Genetic business.industry Aryldialkylphosphatase General Medicine Middle Aged PON1 MicroRNAs chemistry Cardiovascular Diseases Environmental Pollutants Female Gene-Environment Interaction business Biomarkers Biological Monitoring
Zdroj:	Environmental toxicology and pharmacology. 81
ISSN:	1872-7077
Popis:	Cardiovascular diseases (CVDs) are the primary cause of death worldwide. However, little is known about how the interaction between risk factors affects CVDs. Therefore, the aim of this study was to evaluate the effect of the gene-environment interaction (arsenic exposure x PON1 Q192R polymorphism) on serum levels of CVDs biomarkers in Mexican women. Urinary arsenic levels (UAs) ranged from 5.50-145 μg/g creatinine. The allele frequency was 0.38 and 0.62 for the Q and R alleles, respectively. Moreover, significant associations (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c84a3c15ed3fd7915e625eca32dcebd https://pubmed.ncbi.nlm.nih.gov/33164855 Zobrazit plný text záznamu Full Text from ScienceDirect