Human Immunodeficiency Virus Increases the Risk of Incident Heart Failure
| Autor: | Teng Ho Wang, Ming Chung Ko, Chu Chieh Chen, Chung Yeh Deng, Yung Feng Yen, Hsin Hao Lai, Pei Hung Chuang, Muh Yong Yen, Bor Shen Hu |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Anti-HIV Agents Human immunodeficiency virus (HIV) Taiwan HIV Infections 030312 virology medicine.disease_cause Cohort Studies 03 medical and health sciences Acquired immunodeficiency syndrome (AIDS) Risk Factors Internal medicine Antiretroviral Therapy Highly Active medicine Humans Pharmacology (medical) Risk factor Proportional Hazards Models Heart Failure 0303 health sciences Proportional hazards model business.industry Hazard ratio medicine.disease Confidence interval Infectious Diseases Heart failure Case-Control Studies HIV-1 business Cohort study |
| Zdroj: | Journal of acquired immune deficiency syndromes (1999). 80(3) |
| ISSN: | 1944-7884 |
| Popis: | BACKGROUND Although the HIV can cause myocardial inflammation, the association of HIV infection with subsequent development of heart failure (HF) has not been extensively studied. This nationwide cohort study aimed to determine the risk of incident HF in people living with HIV/AIDS (PLWHA). METHODS We identified PLWHA using the Taiwan Centers for Disease Control and Prevention HIV Surveillance System. An age- and sex-matched control group without HIV infection was selected from the Taiwan National Health Insurance Research Database for comparison. All patients were followed up until December 2014 and were observed for a new diagnosis of HF. A time-dependent Cox proportional hazards model was used to determine the association of HIV and highly active antiretroviral therapy with incident HF, with death as a competing risk event. RESULTS Of the 120,765 patients (24,153 PLWHA and 96,612 matched controls), 641 (0.53%) had incident HF during a mean follow-up period of 5.84 years, including 192 (0.79%) PLWHA and 449 (0.46%) controls. Time to diagnosis of incident HF was significantly shorter in PLWHA than in those without HIV infection (P < 0.001, the log-rank test). After adjusting for age, sex, and comorbidities, HIV infection was found to be an independent risk factor for incident HF (adjusted hazard ratio, 1.52; 95% confidence interval: 1.27 to 1.82). As the duration of highly active antiretroviral therapy increased, the risk of HF decreased (P = 0.014). CONCLUSIONS HIV infection was an independent risk factor for incident HF. Clinicians need to be aware of the higher risk of HF in PLWHA. |
| Databáze: | OpenAIRE |
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