Serological evidence of H9N2 avian influenza exposure among poultry workers from Fars province of Iran
| Autor: | Giovanni Cattoli, G. H. Pourghanbari, Isabella Monne, Alessandra Piccirillo, S. Leardini, Kamran Bagheri Lankarani, Alireza Heidari, Marzia Mancin, H. Nili |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Veterinary medicine medicine.medical_specialty Hemagglutination inhibition (HI) viruses Population Avian influenza Hemagglutinin Glycoproteins Influenza Virus Poultry workers Biology Iran medicine.disease_cause Virus Poultry 03 medical and health sciences Seroepidemiologic Studies Occupational Exposure Virology Influenza Human medicine Influenza A Virus H9N2 Subtype Seroprevalence Animals Humans education Phylogeny education.field_of_study Farmers Public health Risk of infection Research virus diseases Microneutralization (MN) H9N2 Influenza A virus subtype H5N1 Titer 030104 developmental biology Infectious Diseases Chickens |
| Zdroj: | Virology Journal |
| Popis: | Background Since the 1990s, influenza A viruses of the H9N2 subtype have been causing infections in the poultry population around the globe. This influenza subtype is widely circulating in poultry and human cases of AI H9N2 have been sporadically reported in countries where this virus is endemic in domestic birds. The wide circulation of H9N2 viruses throughout Europe and Asia along with their ability to cause direct infection in mammals and humans, raises public health concerns. H9N2 AI was reported for the first time in Iran in 1998 and at present it is endemic in poultry. This study was carried out to evaluate the exposure to H9N2 AI viruses among poultry workers from the Fars province. Methods 100 poultry workers and 100 healthy individuals with no professional exposure to poultry took part in this study. Serum samples were tested for antibodies against two distinct H9N2 avian influenza viruses, which showed different phylogenetic clustering and important molecular differences, such as at the amino acid (aa) position 226 (Q/L) (H3 numbering), using haemagglutination inhibition (HI) and microneutralization (MN) assays. Results Results showed that 17 % of the poultry workers were positive for the A/chicken/Iran/10VIR/854-5/2008 virus in MN test and 12 % in HI test using the titer ≥40 as positive cut-off value. Only 2 % of the poultry workers were positive for the A/chicken/Iran/12VIR/9630/1998 virus. Seroprevalence of non exposed individuals for both H9N2 strains was below 3 % by both tests. Statistical analyses models showed that exposure to poultry significantly increases the risk of infection with H9N2 virus. Conclusions The results have demonstrated that exposure to avian H9N2 viruses had occurred among poultry workers in the Fars province of Iran. Continuous surveillance programmes should be implemented to monitor the presence of avian influenza infections in humans and to evaluate their potential threat to poultry workers and public health. Electronic supplementary material The online version of this article (doi:10.1186/s12985-016-0472-z) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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