C-2801X, a new cephamycin-type antibiotic. II. Isolation and characterization
| Autor: | Hidesuke Iwasaki, Masahiko Yoneda, Toru Hasegawa, Hiroshi Fukase, Kazunori Hatano |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
Chemical Phenomena Stereochemistry medicine.drug_class Adipates Antibiotics Amberlite Streptomyces Mice Column chromatography Drug Discovery polycyclic compounds medicine Animals Amino Acids Cephamycins Escherichia coli Infections Pharmacology Chromatography biology Hydrolysis biology.organism_classification Cephalosporins Chemistry Cephamycin Antibacterial activity Bacteria medicine.drug |
| Zdroj: | The Journal of Antibiotics. 29:113-120 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.29.113 |
| Popis: | Two new species of Streptomyces, S. heteromorphus and heteromorphus and S. panayensis, were found to produce a new atibiotic named C-2801X together with cephamycins A and B. The antibiotics were separated from each other by column chromatography on Amberlite XAD-2 and isolated in pure form as mono-sodium salts. C-2801X mono-sodium salt has a molecular formula C25H28N3O12SNa, and exhibits antibacterial activity against Gram-positive and Gram-negative bacteria including those insensitive to cephamycins A and B. From its physicochemical and biological properties, C2801X was considered to be a new cephamycin-type antibiotic. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|