Bacterial Production of a Pederin Analogue by a Free-Living Marine Alphaproteobacterium
| Autor: | Librada M. Cañedo, Paz Zúñiga, Ana Peñalver, Pilar Rodríguez, Carmen Schleissner, Cristina Crespo, Carmen Cuevas, Fernando de la Calle |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Lichens Microbial metabolism Pharmaceutical Science Pederin Marine Biology Analytical Chemistry Microbiology 03 medical and health sciences Polyketide chemistry.chemical_compound Marine bacteriophage Polyketide synthase Drug Discovery Animals Symbiosis Alphaproteobacteria Pyrans Pharmacology Marine biology biology Bacteria Molecular Structure Organic Chemistry Sequence Analysis DNA biology.organism_classification Porifera Coleoptera 030104 developmental biology Complementary and alternative medicine chemistry Multigene Family biology.protein Molecular Medicine Polyketide Synthases |
| Zdroj: | Journal of natural products. 80(7) |
| ISSN: | 1520-6025 |
| Popis: | The polyketide pederin family are cytotoxic compounds isolated from insects, lichen, and marine sponges. During the past decade, different uncultivable bacteria symbionts have been proposed as the real producers of these compounds, such as those found in insects, lichen, and marine sponges, and their trans-AT polyketide synthase gene clusters have been identified. Herein we report the isolation and biological activities of a new analogue of the pederin family, compound 1, from the culture of a marine heterotrophic alphaproteobacterium, Labrenzia sp. PHM005. This is the first report of the production of a pederin-type compound by a free-living marine bacteria that could be cultured in the laboratory. |
| Databáze: | OpenAIRE |
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