Shortened leukocyte telomere length is associated with reduced pulmonary function and greater subsequent decline in function in a sample of World Trade Center responders

Autor: Benjamin J. Luft, Abraham Aviv, Norman H. Edelman, Candace Stewart, Sean A. P. Clouston
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Vital capacity
Longitudinal study
Vital Capacity
lcsh:Medicine
Pulmonary function testing
0302 clinical medicine
DLCO
Diffusing capacity
Forced Expiratory Volume
Leukocytes
Medicine
Longitudinal Studies
Prospective Studies
lcsh:Science
Lung
Multidisciplinary
Inhalation
Lung Injury
respiratory system
Middle Aged
Telomere
3. Good health
Respiratory Function Tests
Cardiology
Female
Respiratory Insufficiency
Adult
medicine.medical_specialty
Senescence
Predictive markers
Article
03 medical and health sciences
FEV1/FVC ratio
Internal medicine
Occupational Exposure
Humans
Retrospective Studies
Occupational health
business.industry
lcsh:R
030104 developmental biology
Spirometry
Multivariate Analysis
lcsh:Q
September 11 Terrorist Attacks
business
030217 neurology & neurosurgery
Biomarkers
Blood sampling
Zdroj: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
ISSN: 2045-2322
Popis: The objective of this study was to examine whether shorter leukocyte telomere length (LTL) is associated with more rapid pulmonary function decline in a longitudinal study of World Trade Center (WTC) responders. WTC responders (N = 284) participating in a monitoring study underwent blood sampling and were followed prospectively for spirometric outcomes. A single blood sample was taken to measure LTL using southern blotting. Outcomes included percent-predicted one-second forced expiratory volume (FEV1%), forced vital capacity (FVC%), and the FEV1/FVC ratio. In a subset, percent-predicted diffusing capacity (DLCO%) was also measured. Longitudinal modeling examined prospectively collected information over five years since blood was banked was used to examine the rate of change in pulmonary functioning over time. Severity of WTC exposure was assessed. Shorter LTL was associated with lower FEV1% and FVC% at baseline. For example, 29.9% of those with LTL
Databáze: OpenAIRE
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