Shortened leukocyte telomere length is associated with reduced pulmonary function and greater subsequent decline in function in a sample of World Trade Center responders
Autor: | Benjamin J. Luft, Abraham Aviv, Norman H. Edelman, Candace Stewart, Sean A. P. Clouston |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Male Vital capacity Longitudinal study Vital Capacity lcsh:Medicine Pulmonary function testing 0302 clinical medicine DLCO Diffusing capacity Forced Expiratory Volume Leukocytes Medicine Longitudinal Studies Prospective Studies lcsh:Science Lung Multidisciplinary Inhalation Lung Injury respiratory system Middle Aged Telomere 3. Good health Respiratory Function Tests Cardiology Female Respiratory Insufficiency Adult medicine.medical_specialty Senescence Predictive markers Article 03 medical and health sciences FEV1/FVC ratio Internal medicine Occupational Exposure Humans Retrospective Studies Occupational health business.industry lcsh:R 030104 developmental biology Spirometry Multivariate Analysis lcsh:Q September 11 Terrorist Attacks business 030217 neurology & neurosurgery Biomarkers Blood sampling |
Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019) |
ISSN: | 2045-2322 |
Popis: | The objective of this study was to examine whether shorter leukocyte telomere length (LTL) is associated with more rapid pulmonary function decline in a longitudinal study of World Trade Center (WTC) responders. WTC responders (N = 284) participating in a monitoring study underwent blood sampling and were followed prospectively for spirometric outcomes. A single blood sample was taken to measure LTL using southern blotting. Outcomes included percent-predicted one-second forced expiratory volume (FEV1%), forced vital capacity (FVC%), and the FEV1/FVC ratio. In a subset, percent-predicted diffusing capacity (DLCO%) was also measured. Longitudinal modeling examined prospectively collected information over five years since blood was banked was used to examine the rate of change in pulmonary functioning over time. Severity of WTC exposure was assessed. Shorter LTL was associated with lower FEV1% and FVC% at baseline. For example, 29.9% of those with LTL |
Databáze: | OpenAIRE |
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