Immune-microbiota interaction in Finnish and Russian Karelia young people with high and low allergy prevalence
| Autor: | Dario Greco, Pekka Jousilahti, Nanna Fyhrquist, Laura Paalanen, Erkki Vartiainen, Harri Alenius, Joseph Ndika, Petri Auvinen, Lars Paulin, Tari Haahtela, Giovanni Scala, Vittorio Fortino, Sari Lehtimäki, Noora Ottman, Tiina Laatikainen, Olga Markelova, Johanna Vendelin, Antti Karkman, Lasse Ruokolainen, Piia Karisola, Mika J. Mäkelä, Leena von Hertzen |
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| Přispěvatelé: | Helsinki Institute of Sustainability Science (HELSUS), Biosciences, Veijo Kaitala / Principal Investigator, University of Helsinki, HUMI - Human Microbiome Research, Research Programs Unit, Institute of Biotechnology, DNA Sequencing and Genomics, Staff Services, Department of Microbiology, HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, Helsinki University Hospital Area, HUSLAB, Faculties, Ruokolainen, Lasse, Fyhrquist, Nanna, Laatikainen, Tiina, Auvinen, Petri, Fortino, Vittorio, Scala, Giovanni, Jousilahti, Pekka, Karisola, Piia, Vendelin, Johanna, Karkman, Antti, Markelova, Olga, Mäkelä, Mika J., Lehtimäki, Sari, Ndika, Joseph, Ottman, Noora, Paalanen, Laura, Paulin, Lar, Vartiainen, Erkki, Hertzen, Leena, Greco, Dario, Haahtela, Tari, Alenius, Harri, Tampere University, BioMediTech |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Allergy Editor‐in‐Chief's Editorial: Basic Mechanisms in Allergic Disease Russia 0302 clinical medicine Genotype Prevalence Immunology and Allergy Gene Regulatory Networks Sensitization Finland Skin education.field_of_study Microbiota Age Factors virus diseases HOUSE-DUST 3. Good health medicine.anatomical_structure DISEASES Original Article Female epidemiology geographic locations Adolescent Immunology Population Biology 3121 Internal medicine Polymorphism Single Nucleotide LONG NONCODING RNAS 03 medical and health sciences Young Adult Immune system omics‐ and systems biology omics- and systems biology Genetic variation medicine Hypersensitivity Humans EXPOSURE education Genetic association Innate immune system Host Microbial Interactions Health Status Disparities Immunoglobulin E medicine.disease Immunity Innate Nasal Mucosa 030104 developmental biology 030228 respiratory system 3121 General medicine internal medicine and other clinical medicine Leukocytes Mononuclear ASTHMA RISK ORIGINAL ARTICLES Transcriptome environment and hygiene hypothesis Genome-Wide Association Study |
| Zdroj: | Clinical and Experimental Allergy |
| Popis: | Background: After the Second World War, the population living in the Karelian region was strictly divided by the “iron curtain” between Finland and Russia. This resulted in different lifestyle, standard of living, and exposure to the environment. Allergic manifestations and sensitization to common allergens have been much more common on the Finnish compared to the Russian side. Objective: The remarkable allergy disparity in the Finnish and Russian Karelia calls for immunological explanations. Methods: Young people, aged 15-20 years, in the Finnish (n = 69) and Russian (n = 75) Karelia were studied. The impact of genetic variation on the phenotype was studied by a genome-wide association analysis. Differences in gene expression (transcriptome) were explored from the blood mononuclear cells (PBMC) and related to skin and nasal epithelium microbiota and sensitization. Results: The genotype differences between the Finnish and Russian populations did not explain the allergy gap. The network of gene expression and skin and nasal microbiota was richer and more diverse in the Russian subjects. When the function of 261 differentially expressed genes was explored, innate immunity pathways were suppressed among Russians compared to Finns. Differences in the gene expression paralleled the microbiota disparity. High Acinetobacter abundance in Russians correlated with suppression of innate immune response. High-total IgE was associated with enhanced anti-viral response in the Finnish but not in the Russian subjects. Conclusions and clinical relevance: Young populations living in the Finnish and Russian Karelia show marked differences in genome-wide gene expression and host contrasting skin and nasal epithelium microbiota. The rich gene-microbe network in Russians seems to result in a better-balanced innate immunity and associates with low allergy prevalence. publishedVersion |
| Databáze: | OpenAIRE |
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