Chemically induced dimerization: reversible and spatiotemporal control of protein function in cells
| Autor: | Laura Klewer, Yao-Wen Wu, Stephanie Voß |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Protein function
Chemistry Cell Membrane Proteins Nanotechnology Biochemistry Protein multimerization Analytical Chemistry Transport protein Protein Transport Proteins metabolism Biophysics Animals Humans Chemically induced dimerization Spatiotemporal resolution Protein Multimerization Signal transduction Protein trafficking Signal Transduction |
| Zdroj: | Current Opinion in Chemical Biology. 28:194-201 |
| ISSN: | 1367-5931 |
| Popis: | Small-molecule perturbation of biological systems is able to tackle biological problems that are not accessible by classical genetic interference methods. Chemically induced dimerization (CID) has been used as a valuable tool to study various biological processes. Recent years have seen tremendous progress in the development of orthogonal and reversible CID systems. These new systems allow control over protein function with unprecedented precision and spatiotemporal resolution. While the primary application of CID has been on dissecting signal transductions, new emerging approaches have extended the scope of this technique to elucidating membrane and protein trafficking. |
| Databáze: | OpenAIRE |
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