Effect of Screening Mammography on Breast-Cancer Mortality in Norway
| Autor: | Marvin Zelen, Hans-Olov Adami, Mette Kalager, Frøydis Langmark |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Breast Neoplasms Rate ratio Young Adult Breast cancer Epidemiology medicine Humans Mass Screening Mammography Aged Aged 80 and over Gynecology medicine.diagnostic_test Norway business.industry Obstetrics Incidence Incidence (epidemiology) Cancer General Medicine Middle Aged medicine.disease Cancer registry Female Breast disease business |
| Zdroj: | New England Journal of Medicine. 363:1203-1210 |
| ISSN: | 1533-4406 0028-4793 |
| Popis: | Background A challenge in quantifying the effect of screening mammography on breast-cancer mortality is to provide valid comparison groups. The use of historical control subjects does not take into account chronologic trends associated with advances in breastcancer awareness and treatment. Methods The Norwegian breast-cancer screening program was started in 1996 and expanded geographically during the subsequent 9 years. Women between the ages of 50 and 69 years were offered screening mammography every 2 years. We compared the incidence-based rates of death from breast cancer in four groups: two groups of women who from 1996 through 2005 were living in counties with screening (screening group) or without screening (nonscreening group); and two historical-comparison groups that from 1986 through 1995 mirrored the current groups. Results We analyzed data from 40,075 women with breast cancer. The rate of death was reduced by 7.2 deaths per 100,000 person-years in the screening group as compared with the historical screening group (rate ratio, 0.72; 95% confidence interval [CI], 0.63 to 0.81) and by 4.8 deaths per 100,000 person-years in the nonscreening group as compared with the historical nonscreening group (rate ratio, 0.82; 95% CI, 0.71 to 0.93; P |
| Databáze: | OpenAIRE |
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