Next Stage Approach to Tissue Engineering Skeletal Muscle
| Autor: | Fabio Magarotto, Gregory Reid, Anna Marsano, Michela Pozzobon |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
lcsh:T
Regeneration (biology) Extracellular vesicles Growth factors Neuro‐angiogenesis Skeletal muscle engineering Skeletal muscle Bioengineering Review Biology Muscle injury neuro-angiogenesis lcsh:Technology Alternative treatment medicine.anatomical_structure lcsh:Biology (General) Tissue engineering growth factors medicine skeletal muscle engineering extracellular vesicles Tissue composition lcsh:QH301-705.5 Neuroscience Process (anatomy) Function (biology) |
| Zdroj: | Bioengineering, Vol 7, Iss 118, p 118 (2020) Bioengineering |
| ISSN: | 2306-5354 |
| DOI: | 10.3390/bioengineering7040118 |
| Popis: | Large-scale muscle injury in humans initiates a complex regeneration process, as not only the muscular, but also the vascular and neuro-muscular compartments have to be repaired. Conventional therapeutic strategies often fall short of reaching the desired functional outcome, due to the inherent complexity of natural skeletal muscle. Tissue engineering offers a promising alternative treatment strategy, aiming to achieve an engineered tissue close to natural tissue composition and function, able to induce long-term, functional regeneration after in vivo implantation. This review aims to summarize the latest approaches of tissue engineering skeletal muscle, with specific attention toward fabrication, neuro-angiogenesis, multicellularity and the biochemical cues that adjuvate the regeneration process. |
| Databáze: | OpenAIRE |
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