Atorvastatin efficiency after traumatic brain injury in rats
| Autor: | Oktay Gurcan, Hakan Eroglu, Mustafa F. Sargon, Ozerk Okutan, Omer Faruk Turkoglu, Levent Öner, Etem Beskonakli, Ebru Bodur |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Traumatic brain injury medicine.medical_treatment Atorvastatin Brain Edema Cerebral edema Rats Sprague-Dawley Lipid peroxidation Random Allocation chemistry.chemical_compound Microscopy Electron Transmission Internal medicine medicine Animals Pyrroles Craniotomy Analysis of Variance biology business.industry Microcirculation Brain Organ Size medicine.disease Malondialdehyde Rats Disease Models Animal Neuroprotective Agents Endocrinology chemistry Heptanoic Acids Brain Injuries Cerebrovascular Circulation Anesthesia HMG-CoA reductase biology.protein Surgery Lipid Peroxidation Neurology (clinical) Analysis of variance business medicine.drug |
| Zdroj: | Surgical Neurology. 72:146-152 |
| ISSN: | 0090-3019 |
| Popis: | Background The neuroprotective effects of statins possibly depend on their pleiotropic effect such as antioxidative and anti-inflammatory properties. In this study, we have evaluated the efficiency of atorvastatin on brain edema, lipid peroxidation, and ultrastructural changes in TBI animal model. Methods Modified Feeney method has been used for the trauma model in rats. Only craniectomy for group A and trauma after craniectomy for group B was the procedure for animals. For the trauma, rods weighing 24 g were dropped on a foot plate just over the dura. Atorvastatin (1 mg/kg, IP) was administered to the animals in group C after craniectomy and trauma; but on the other hand, animals in group D received only 0.5 mL PEG as the vehicle. Brains were harvested 24 hours after the trauma for the assays of wet-dry weight, lipid peroxidation level, and ultrastructural investigations. Lipid peroxidation levels, TEM, and UNGS were the investigated parameters. The statistical comparisons between the groups were investigated by 1-way ANOVA and post hoc analysis by Duncan and Dunnett T3 test within the groups at the significance level P = .05. Results Trauma increased water contents of the brain tissues and lipid peroxidation levels in groups B and D. When compared with the results of group B (brain edema, 84.694% ± 1.510%; lipid peroxidation, 74.932 ± 2.491 nmol/g tissue), atorvastatin (1 mg/kg) significantly decreased brain edema (77.362% ± 1.448%), lipid peroxidation level (58.335 ± 3.980 nmol/g tissue), and UNGS scores in group C ( P Conclusion In this descriptive study, the remarkable improvements of atorvastatin on brain edema, lipid peroxidation, and ultrastructural investigations encouraged us for a further dose optimization study. |
| Databáze: | OpenAIRE |
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