Histoenzymological characteristics of the heart conduction system: comparative study with left or right ventricle afterload
| Autor: | V. V. Sukhoparova, V. Yu. Klyuchikov, N. A. Bobrova, M. Kh. Kadyrova, M. S. Tverskaya |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Pulmonary Circulation Heart Ventricles Guinea Pigs Ventricular Septum Pulmonary Artery General Biochemistry Genetics and Molecular Biology Afterload Heart Conduction System medicine.artery Internal medicine medicine Animals Myocytes Cardiac Heart Failure Aorta Pulmonary artery stenosis business.industry Myocardium General Medicine Aortic Valve Stenosis medicine.disease Myocardial Contraction Pulmonary Valve Stenosis Stenosis medicine.anatomical_structure Ventricle Heart failure Pulmonary artery cardiovascular system Cardiology Electrical conduction system of the heart business Glycolysis |
| Zdroj: | Bulletin of experimental biology and medicine. 155(5) |
| ISSN: | 1573-8221 |
| Popis: | Histoenzymological changes, indicating inhibition of the main metabolic processes, were found in the conduction cardiomyocytes of the left ventricle and ventricular septum in experimental stenosis of the aorta. The histoenzymological changes in the conduction system of both ventricles and ventricular septum were similar in experimental stenosis of the pulmonary artery and indicated primarily activation of glycolysis. The histoenzymological profi le of conduction cardiomyocytes differed little in cases when the increase of the pressure load was complicated or not complicated by the development of heart failure, particularly in pulmonary artery stenosis. The histoenzymological changes in the conduction system in response to increased afterload differed significantly from those in the contractile myocardium and correlated with the level of cellular functional activity and sensitivity to the regulatory and alterative exposure. These data attest to minor role of metabolic shifts in conduction cell injuries with increasing afterload, primarily, of the right ventricle. |
| Databáze: | OpenAIRE |
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