A hyaluronic acid- and chondroitin sulfate-based medical device improves gastritis pain, discomfort, and endoscopic features
| Autor: | Maria Vadalà, V. Boarino, Carmen Laurino, Beniamino Palmieri, Julio César Morales-Medina, Alberto Merighi, Tommaso Iannitti |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Visual analogue scale Pharmaceutical Science Pain Placebo Gastroenterology Anecdotes as Topic 03 medical and health sciences chemistry.chemical_compound Random Allocation Young Adult 0302 clinical medicine Edema Internal medicine Hyaluronic acid Clinical endpoint medicine Humans Chondroitin sulfate Endoscopy Digestive System Hyaluronic Acid Child Aged Retrospective Studies Aged 80 and over medicine.diagnostic_test business.industry Chondroitin Sulfates Double Bind Interaction Middle Aged Endoscopy Treatment Outcome chemistry Equipment and Supplies 030220 oncology & carcinogenesis Gastritis 030211 gastroenterology & hepatology Female medicine.symptom business |
| Zdroj: | Drug delivery and translational research. 8(5) |
| ISSN: | 2190-3948 |
| Popis: | Gastritis is an inflammation of the gastric mucosa. In this study, we investigated the efficacy of a medical device, Esoxx®, based on hyaluronic acid and chondroitin sulfate on gastritis-related upper abdominal pain/discomfort and endoscopic features. Fifty patients, affected by gastritis, were randomised to receive the medical device or placebo. The primary endpoint was the medical device efficacy on upper abdominal pain/discomfort associated with gastritis and measured by Visual Analogue Scale (VAS). The secondary endpoints were the efficacy of the medical device on gastritis-related mucosal erosions, blood oozing, and hyperemia (redness)/edema, as assessed by endoscopy, and the patients’ rating of their compliance with the treatments. A significant reduction in VAS pain was observed in the treatment group after a 5-week treatment, if compared with placebo (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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