Increased Urinary Cortisol and Androgen Metabolites in a Young Female with Hypertension: Partial Glucocorticoid Resistance Syndrome
| Autor: | Mohammed Yousufuddin, Ameet Bakhai, Andrew J.S. Coats, Waqar Shamim |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty Ambulatory blood pressure Hydrocortisone Urinary system Blood Pressure chemistry.chemical_compound Internal medicine Renin–angiotensin system medicine Humans Pharmacology (medical) Diltiazem Glucocorticoids Aldosterone business.industry Syndrome Blood Pressure Monitoring Ambulatory Amiloride Endocrinology chemistry Hypertension Androgens Female Cardiology and Cardiovascular Medicine business Biomarkers Glucocorticoid medicine.drug |
| Zdroj: | Cardiology. 93:131-132 |
| ISSN: | 1421-9751 0008-6312 |
| Popis: | A 21-year-old woman with hypertension confirmed on ambulatory blood pressure monitoring and unresponsive to β-blockers, diltiazem and amiloride was found to have serum potassium, renin and aldosterone levels at or just below the lower end of normal. Urinary glucocorticoid metabolite analysis revealed high excretion of cortisol and androgen metabolites, with normal serum cortisol levels. This pattern suggests a partial glucocorticoid resistance syndrome; such patients are more responsive to ACE inhibitors and spironolactone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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