Early Appearance of Epicardial Adipose Tissue through Human Development
| Autor: | Marta Garaulet, Vanesa Jiménez-Ortega, Ana I. Esquifino, Gregorio Varela-Moreiras, Juliana Pérez-Miguelsanz, Pilar Cano-Barquilla, Pilar Fernández-Mateos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Angiogenesis Ginecología y obstetricia Mesenchyme Dietética y nutrición Gestational Age metabolic fetal programing Intra-Abdominal Fat Article Extracellular matrix Fetal Development Fetus Pregnancy cardiovascular disease Endocrinología Adipocytes Medicine Humans TX341-641 Obesity Full Term epicardial adipose tissue development Nutrition and Dietetics Adipogenesis business.industry Nutrition. Foods and food supply Myocardium Embryo Coronary Vessels Coronary arteries medicine.anatomical_structure Dietética Adipose Tissue Nutrición Cardiovascular Diseases human embryo and fetus Female business Pericardium coronary arteries Food Science |
| Zdroj: | Nutrients, Vol 13, Iss 2906, p 2906 (2021) Nutrients Volume 13 Issue 9 E-Prints Complutense. Archivo Institucional de la UCM Universidad Europea (UEM) |
| ISSN: | 2072-6643 |
| Popis: | Background: Epicardial adipose tissue (EAT) is a visceral fat depot with unique anatomic, biomolecular and genetic features. Due to its proximity to the coronary arteries and myocardium, dysfunctional EAT may contribute to the development and progression of cardiovascular and metabolic-related adiposity-based chronic diseases. The aim of this work was to describe, by morphological techniques, the early origin of EAT. Methods: EAT adipogenesis was studied in 41 embryos from 32 gestational days (GD) to 8 gestational weeks (GW) and in 23 fetuses until full term (from 9 to 36 GW). Results: This process comprises five stages. Stage 1 appears as mesenchyme at 33–35 GD. Stage 2 is characterized by angiogenesis at 42–45 GD. Stage 3 covers up to 34 GW with the appearance of small fibers in the extracellular matrix. Stage 4 is visible around the coronary arteries, as multilocular adipocytes in primitive fat lobules, and Stage 5 is present with unilocular adipocytes in the definitive fat lobules. EAT precursor tissue appears as early as the end of the first gestational month in the atrioventricular grooves. Unilocular adipocytes appear at the eighth gestational month. Conclusions: Due to its early origin, plasticity and clinical implications, factors such as maternal health and nutrition might influence EAT early development in consequence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|