MLC901, a Traditional Chinese Medicine protects the brain against global ischemia

Autor: Fabien Labbal, M Lazdunski, J. Veyssiere, Hervé Quintard, Marc Borsotto, Catherine Heurteaux, C. Gandin, Catherine Widmann
Přispěvatelé: Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), CHU Nice, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)
Rok vydání: 2011
Předmět:
Male
Necrosis
MESH: Rats
Neurogenesis
medicine.medical_treatment
Ischemia
Morris water navigation task
NeuroAid
Pharmacology
Neuroprotection
Brain Ischemia
Brain ischemia
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Recovery
Animals
MESH: Medicine
Chinese Traditional
Medicine
MESH: Animals
Medicine
Chinese Traditional
Rats
Wistar
Global ischemia
PI3K/AKT/mTOR pathway
030304 developmental biology
0303 health sciences
business.industry
Akt
MESH: Drugs
Chinese Herbal
MESH: Brain Ischemia
Neuroaid
MESH: Neuroprotective Agents
MESH: Rats
Wistar
[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
medicine.disease
MESH: Male
Rats
3. Good health
Neuroprotective Agents
BDNF
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
medicine.symptom
business
Neuroscience
030217 neurology & neurosurgery
Drugs
Chinese Herbal
Zdroj: Neuropharmacology
Neuropharmacology, Elsevier, 2011, 61 (4), pp.622-31. ⟨10.1016/j.neuropharm.2011.05.003⟩
ISSN: 0028-3908
Popis: International audience; Global ischemia leads to damage in the hippocampal CA1 region and is associated with behavioral deficits. NeuroAid (MLC601 and MLC901), a Traditional Chinese Medicine is used in China for patients after stroke. We have investigated here the effects of MLC901 on brain injury and deficits after global ischemia in the rat. Global ischemia induced by four-vessel occlusion resulted in degeneration of CA1 neurons. MLC901 (0.074 mg/ml) prevented both necrosis and apoptosis of neurons up to 3 h after ischemia. These positive MLC901 effects were associated with a decrease in Bax expression and in levels of the lipid peroxidation product malondialdehyde. Using the PI3-kinase inhibitor LY294002 we also demonstrated the critical role of the Akt pathway in MLC901-mediated neuroprotection. MLC901 enhanced neurogenesis. Furthermore, MLC901 improved functional recovery of rats after global ischemia as assessed by the Morris water maze. In this test MLC901 reduced the increase in escape latency and in swim distance induced by ischemia. MLC901 also improved post-ischemic grip strength. If observations made with rats can be extended to humans, then MLC901 will represent a novel therapeutic strategy after cardiac arrest with a clinically interesting time window of protection.
Databáze: OpenAIRE
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