β-Cyclodextrin counteracts obesity in Western diet-fed mice but elicits a nephrotoxic effect
| Autor: | Loes M. Butter, Marius A. van den Bergh Weerman, Angelique M. L. Scantlebery, Peter Ochodnicky, Nike Claessen, Sandrine Florquin, Joris J. T. H. Roelofs, Jaklien C. Leemans, Chaima El Boumashouli, Gwen J. Teske, Elena Rampanelli, Lotte Kors |
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| Přispěvatelé: | Graduate School, Pathology, ACS - Diabetes & metabolism, ACS - Pulmonary hypertension & thrombosis, AGEM - Endocrinology, metabolism and nutrition, AGEM - Inborn errors of metabolism, AII - Inflammatory diseases, Vascular Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty lcsh:Medicine Adipose tissue Inflammation Disease Kidney Article Nephrotoxicity Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Fibrosis Internal medicine medicine Animals Obesity Drug safety lcsh:Science Phospholipids Triglycerides Hypolipidemic Agents Multidisciplinary business.industry Cholesterol beta-Cyclodextrins lcsh:R medicine.disease Lipids Mice Inbred C57BL Disease Models Animal 030104 developmental biology Endocrinology Liver chemistry Diet Western 030220 oncology & carcinogenesis Kidney Diseases lcsh:Q medicine.symptom business Weight gain |
| Zdroj: | Scientific reports, 9(1):17633. Nature Publishing Group Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019) Scientific Reports |
| Popis: | Obesity has become a worldwide health crisis and is associated with a plethora of comorbidities. The multi-organ effects of obesity have been linked to ectopic lipid accumulation. Thus, there is an urgent need to tackle the obesity crisis by developing effective lipid-lowering therapies. 2-hydroxypropyl-β-Cyclodextrin (2HP-β-CD) has been previously shown to reduce lysosomal cholesterol accumulation in a murine model of Niemann Pick Type C (NPC) disease. Using a murine model of Western diet-induced obesity (DIO), we report the effects of 2HP-β-CD in counteracting weight gain, expansion of adipose tissue mass and ectopic lipid accumulation. Interestingly, DIO caused intracellular storage of neutral lipids in hepatic tissues and of phospholipids in kidneys, both of which were prevented by 2HP-β-CD. Importantly, this report brings attention to the nephrotoxic effects of 2HP-β-CD: renal tubular damage, inflammation and fibrosis. These effects may be overlooked, as they are best appreciated upon assessment of renal histology. |
| Databáze: | OpenAIRE |
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