Adrenocortical axis responses to adrenergic and glutamate stimulation are regulated by the amygdala
| Autor: | Michael E. Newman, Anna Itzik, Joseph Weidenfeld, Shaul Feldman |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Agonist Hypothalamo-Hypophyseal System medicine.medical_specialty medicine.drug_class Radioimmunoassay Glutamic Acid Pituitary-Adrenal System Adrenergic Stimulation Amygdala Norepinephrine Adrenocorticotropic Hormone Internal medicine Basal ganglia medicine Animals Chemistry General Neuroscience Glutamate receptor Electric Stimulation Rats medicine.anatomical_structure Endocrinology nervous system Hypothalamus Corticosterone Neuroscience medicine.drug |
| Zdroj: | NeuroReport. 16:1245-1249 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-200508010-00023 |
| Popis: | We have examined the effect of lesions of the central and medial amygdala on the pituitary-adrenal responses to noradrenergic stimulation and to the injection of glutamate into the paraventricular nucleus. Bilateral lesions of the amygdalar nuclei inhibited adrenocorticotrophic hormone and corticosterone responses to electrical stimulation of the ventral noradrenergic bundle, and to the injection of the alpha1-adrenergic agonist phenylephrine or glutamate. These results suggest that the amygdala may facilitate the stimulatory roles of noradrenaline and glutamate on the adrenocortical axis. The data contribute to understanding the mechanisms by which the amygdala is involved in the function of this axis. |
| Databáze: | OpenAIRE |
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