Characterizing the Utility and Limitations of Repurposing an Open-Field Optical Imaging Device for Fluorescence-Guided Surgery in Head and Neck Cancer Patients
| Autor: | Andrew C. Prince, Lindsay S. Moore, Joshua S. Richman, Esther de Boer, Jason M. Warram, Eben L. Rosenthal, William R. Carroll, E. Scott Young, Kurt R. Zinn, Neel Patel, Melissa L. Korb, Erika M Walsh, Anthony B. Morlandt, Kirk Withrow, Todd M. Stevens, Thomas K. Chung |
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| Rok vydání: | 2016 |
| Předmět: |
Male
OROPHARYNGEAL CANCER Fluorescence-lifetime imaging microscopy Perfusion scanning 030218 nuclear medicine & medical imaging chemistry.chemical_compound 0302 clinical medicine Medicine MARGINS SPECIFICITY Repurposing Margins of Excision Equipment Design Middle Aged Treatment Outcome Surgery Computer-Assisted Oncology Head and Neck Neoplasms SURGICAL-TREATMENT 030220 oncology & carcinogenesis Female SQUAMOUS-CELL CARCINOMA NEAR-INFRARED FLUORESCENCE fluorescence-guided surgery Adult medicine.medical_specialty RESECTION 5-AMINOLEVULINIC ACID Sensitivity and Specificity optical imaging 03 medical and health sciences Optical imaging CETUXIMAB-IRDYE800 Equipment Reuse Humans Tomography Optical XENOGRAFTS Radiology Nuclear Medicine and imaging Aged business.industry Head and neck cancer Reproducibility of Results Cancer medicine.disease Surgery Equipment Failure Analysis Clinical trial Microscopy Fluorescence chemistry head and neck cancer business Indocyanine green |
| Zdroj: | Journal of Nuclear Medicine, 58(2), 246-251. SOC NUCLEAR MEDICINE INC |
| ISSN: | 2159-662X 0161-5505 |
| DOI: | 10.2967/jnumed.115.171413 |
| Popis: | The purpose of this study was to assess the potential of U.S. Food and Drug Administration-cleared devices designed for indocyanine green-based perfusion imaging to identify cancer-specific bioconjugates with overlapping excitation and emission wavelengths. Recent clinical trials have demonstrated potential for fluorescence guided surgery, but the time and cost of the approval process may impede clinical translation. To expedite this translation, we explored the feasibility of repurposing existing optical imaging devices for fluorescence-guided surgery. Methods: Consenting patients (n = 15) scheduled for curative resection were enrolled in a clinical trial evaluating the safety and specificity of cetuximab-IRDye800 (NCT01987375). Open-field fluorescence imaging was performed preoperatively and during the surgical resection. Fluorescence intensity was quantified using integrated instrument software, and the tumor-to-background ratio characterized fluorescence contrast. Results: In the preoperative clinic, the open-field device demonstrated potential to guide preoperative mapping of tumor borders, optimize the day of surgery, and identify occult lesions. Intraoperatively, the device demonstrated robust potential to guide surgical resections, as all peak tumor-to-background ratios were greater than 2 (range, 2.2-14.1). Postresection wound bed fluorescence was significantly less than preresection tumor fluorescence (P |
| Databáze: | OpenAIRE |
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