Small Vessel Vasculitis in Herpes Zoster—Discussion of Current Aspects of Varicella Zoster Virus Vasculopathy
| Autor: | Sigrun Smola, Cornelia S. L. Müller, Barbara Burgard, Thomas Vogt |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Vasculitis Herpesvirus 3 Human Pathology medicine.medical_specialty viruses Central nervous system Inflammation Dermatology medicine.disease_cause Herpes Zoster Skin Diseases Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Humans Medicine Aged integumentary system business.industry Varicella zoster virus virus diseases General Medicine CELL DEBRIS medicine.disease Small vessel vasculitis medicine.anatomical_structure Giant cell Herpes Zoster Ophthalmicus medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | The American Journal of Dermatopathology. 40:602-604 |
| ISSN: | 0193-1091 |
| Popis: | Varicella zoster virus (VZV) vasculopathy was initially described as herpes zoster ophthalmicus with contralateral hemiplegia in 1896. VZV is able to infect endothelial cells directly, leading to a thickened intima and vascular remodeling due to inflammation. Therefore, a spectrum of vasculopathies is induced, ranging from a discrete capillaritis-to-granulomatous vasculitis and obliterative angiitis. Cutaneous vasculitic changes sui generis with leukocytoclasia, cell debris, vascular damage, and endothelial swelling are very rare feature of herpetic infections in skin biopsies. We report an immunocompetent patient who presented with a rare form of cutaneous VZV infection of the upper leg characterized by vasculitic changes of the small vessels without typical herpetic epidermal features or neural involvement. Intriguingly, the vasculitis appeared prior to the characteristic vesicular rush without any pain symptoms. Because VZV can cause vasculopathic damage mainly within the central nervous system in immunocompetent and immunosuppressed patients, we recommend continuous clinical controls to recognize central symptoms that are related to VZV vasculopathy or giant cell arteriitis. |
| Databáze: | OpenAIRE |
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