Neuropsychiatric syndrome with myoclonus after SARS-CoV-2 infection in a paediatric patient
| Autor: | M, Della Corte, C, Delehaye, E, Savastano, M F, De Leva, P, Bernardo, A, Varone |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Male
Myoclonus Case Report Neuropsychological Tests EEG electroencephalogram IVIG Intravenous Immunoglobulin VC Verbal Comprehension Humans Immunologic Factors Attention PR Perceptual Reasoning Child CSF Cerebrospinal fluid Mental Disorders COVID-19 Immunoglobulins Intravenous Syndrome COVID-19 Coronavirus Disease General Medicine CNS Central Nervous System Neurological complications Paediatric WM Working Memory PS Processing Speed Surgery Neurology (clinical) MRI magnetic resonance imaging Psychomotor Performance |
| Zdroj: | Clinical Neurology and Neurosurgery |
| ISSN: | 0303-8467 |
| DOI: | 10.1016/j.clineuro.2022.107121 |
| Popis: | We report the case of a 12-years-old patient who subacutely developed a positive and negative myoclonus of limbs and face, drowsiness and memory deficits after getting infected by SARS-CoV-2. On admission, nasopharyngeal swab for SARS-CoV-2, brain and spinal MRI with and without contrast, EEG, chest X-ray and abdominal ultrasound were negative. CSF physical-chemical examination, culture, PCR testing for SARS-CoV-2 and other pathogens, and oligoclonal IgG bands were negative as well. A full panel blood test, including clotting, autoimmunity and paraneoplastic blood studies, did not show any alteration. The neuropsychological examination showed an impairment in memory, visual-motor coordination, inductive reasoning skills, attention, and concentration. The patient was first treated with clonazepam and then with intravenous methylprednisolone for five days, with poor response. For this reason, he then received a cycle of IVIG, thus reaching a gradual and complete recovery. To date, this is the first case of a COVID-19 associated myoclonus affecting a paediatric patient. |
| Databáze: | OpenAIRE |
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