Phospholipid patterns of erythrocytes in schizophrenia: relationships to symptomatology
| Autor: | Gregory Barshtein, Shimon Lecht, Ilan Modai, Lev D. Bergelson, Yakov Nechamkin, S. Yedgar, Michael S. Ritsner, Alexander M. Ponizovsky |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Erythrocytes Hallucinations Phospholipid chemistry.chemical_compound Reference Values Internal medicine Schizophrenic Psychology medicine Humans Phospholipids Biological Psychiatry Psychiatric Status Rating Scales Phosphatidylethanolamine Positive and Negative Syndrome Scale Depression Phosphatidylserine Middle Aged medicine.disease Psychiatry and Mental health Red blood cell medicine.anatomical_structure Endocrinology chemistry Schizophrenia Immunology Female Psychology |
| Zdroj: | Schizophrenia Research. 52:121-126 |
| ISSN: | 0920-9964 |
| Popis: | The phospholipid composition of red blood cells (RBC) from 32 haloperidol-treated schizophrenic patients, classified according to the positive and negative syndrome scale (PANSS) as showing either predominantly positive or predominantly negative symptoms, was determined and compared with that of normal controls. While the levels of phosphatidylcholine and phosphatidylserine were similar in all three groups, sphingomyelin (SM) and phosphatidylethanolamine (PE) were, respectively, increased and decreased in RBCs of schizophrenic patients. In both patient groups, the SM/PE ratios correlated directly with the PANSS negative symptom scale scores and inversely with the positive symptom scale scores. However, the inverse changes in the contents of SM and PE were much more expressed in the negative group. It is suggested that a main source of that difference is a higher activity of the polyunsaturated acid-selective phospholipase A(2) in the negative syndrome patients than in the positive syndrome and control groups. |
| Databáze: | OpenAIRE |
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