Development of new drug delivery system for protein drugs using silicone (I)

Autor:	Masako Kajihara, Toshihiko Sugie, Masayuki Mizuno, Nobuhiko Tamura, Akihiko Sano, Keiji Fujioka, Yasuo Kashiwazaki, Takashi Yamaoka, Shuichi Sugawara, Yosuke Urabe
Rok vydání:	2000
Předmět:	Microscopy Confocal Glycine Silicones Pharmaceutical Science Interferon-alpha Mice Nude Kinetics Mice Solubility Osmotic Pressure Delayed-Action Preparations Tumor Cells Cultured Animals Female Dimethylpolysiloxanes Particle Size Powders Neoplasm Transplantation
Zdroj:	Journal of controlled release : official journal of the Controlled Release Society. 66(1)
ISSN:	0168-3659
Popis:	A novel technique, by which protein drugs effective in small doses can be released over a long period, was developed using silicone and a water-soluble substance. In this study, interferon (IFN) was used as a model of the protein drugs. The IFN-silicone formulation released IFN over long periods of time in vitro and suppressed tumor growth in nude mice for about 100 days after a single administration. This indicates that physiologically active IFN is released over a prolonged period of time from the IFN-silicone formulation in vivo. Silicone formulations are expected to be a practically feasible sustained-release formulation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c66eff1e93c47d2ebe54844fdc018fa https://pubmed.ncbi.nlm.nih.gov/10708878 Zobrazit plný text záznamu Full Text from ScienceDirect