Prevalence of Ectopic Ventricular Activity After Left Ventricular Mass Regression
| Autor: | Pedro J. Rodríguez, Luis Miguel Camacho Díaz, Jorge E. Lugo, Jose Fernández-Martínez, Cinthya Vargas, Robert A. González-fernández, Ileana Torres, Mercedes Rivera, Luis H. Soltero |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Cardiac Complexes Premature medicine.medical_specialty Captopril Heart Ventricles Cardiomegaly Placebo Left ventricular hypertrophy Muscle hypertrophy Double-Blind Method Internal medicine Internal Medicine medicine Humans Ventricular Function cardiovascular diseases biology medicine.diagnostic_test business.industry Angiotensin-converting enzyme Middle Aged medicine.disease Blood pressure Echocardiography Hypertension biology.protein Cardiology Female Complication business Electrocardiography medicine.drug |
| Zdroj: | American Journal of Hypertension. 6:308-313 |
| ISSN: | 1941-7225 0895-7061 |
| DOI: | 10.1093/ajh/6.4.308 |
| Popis: | To assess the effects of left ventricular mass reduction on the prevalence of ventricular ectopic activity, we conducted a double-blind, placebo-controlled trial measuring ambulatory 48 h premature ventricular depolarizations in 27 patients with mild-to-moderate hypertension and an increased left ventricular mass index. Data was obtained at baseline and 6 +/- 2 months after randomization to either 25 mg captopril or placebo twice a day. Patients on captopril attained reduction in blood pressure from 167 +/- 11/103 +/- 6 to 136 +/- 10/85 +/- 5 mm Hg (P = .001), left ventricular mass index regression from 149 +/- 17 to 96 +/- 23 g/m2 (P = .001), and ventricular ectopic activity reduction from 413 +/- 172 to 77 +/- 27 ventricular extrasystoles/day (P = .001). Patients on placebo had no significant change in blood pressure (from 162 +/- 11/101 +/- 6 at baseline to 160 +/- 8/100 +/- 8 mm Hg after 6 months; P = NS). In the placebo group left ventricular mass index increased from 155 +/- 40 to 182 +/- 51 g/m2 (P = .01), and ventricular ectopic activity decreased from 634 +/- 293 to 562 +/- 260 ventricular extrasystoles/day (P = NS). Eight out of 14 patients on captopril (57%) and 1 out of 13 patients on placebo (8%) achieved reduction > 85% in ventricular ectopic activity per day (P = .004). Using multivariate logistic regression analysis, left ventricular mass index regression and reduction in systolic blood pressure were the most important correlates for this effect.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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