Successful Treatment with Alectinib for Choroidal Metastasis in Anaplastic Lymphoma Kinase Rearranged Non-small Cell Lung Cancer
| Autor: | Toshiaki Wakayama, Masato Taki, Tomoko Funazo, Kazuhiko Nakagawa, Naoya Ikegami, Ryo Ariyasu, Chie Yoshimura, Chisato Konishi, Moon Hee Hwang, Satoshi Nakao, Yasuo Nishizaka, Kyohei Morita |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Oncology
Alectinib Adult medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Carbazoles non-small cell lung cancer (NSCLC) Case Report Antineoplastic Agents Targeted therapy 03 medical and health sciences 0302 clinical medicine Asian People Piperidines Internal medicine hemic and lymphatic diseases Carcinoma Non-Small-Cell Lung Internal Medicine medicine Anaplastic lymphoma kinase Humans alectinib Anaplastic Lymphoma Kinase Neoplasm Metastasis Lung cancer Protein Kinase Inhibitors Chemotherapy business.industry Choroid Neoplasms Cancer Receptor Protein-Tyrosine Kinases General Medicine choroidal metastasis medicine.disease eye diseases Radiation therapy anaplastic lymphoma kinase (ALK) 030220 oncology & carcinogenesis 030221 ophthalmology & optometry Female sense organs business |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | Choroidal metastasis is rare in cancer patients and it may cause visual disturbances that reduce their quality of life. In non-small cell lung cancer (NSCLC), targeted therapy against actionable driver mutations has gradually replaced radiotherapy as the treatment of choice for choroidal metastasis. Recently, there have been several case reports of choroidal metastasis in patients with anaplastic lymphoma kinase (ALK)-rearranged NSCLC. We herein report the case of a 40-year-old Japanese woman diagnosed with choroidal metastasis of an ALK-rearranged NSCLC who received alectinib as the first-line chemotherapy. Alectinib may be the best treatment for choroidal metastasis in patients harboring an ALK translocation because of its favorable side effect profile involving visual disturbances. |
| Databáze: | OpenAIRE |
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