Peripheral Biomarkers in Manifest and Premanifest Huntington’s Disease
| Autor: | Emanuele Morena, Carmela Romano, Martina Marconi, Selene Diamant, Maria Chiara Buscarinu, Gianmarco Bellucci, Silvia Romano, Daniela Scarabino, Marco Salvetti, Giovanni Ristori |
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| Rok vydání: | 2023 |
| Předmět: |
mHTT
manifest Organic Chemistry premanifest General Medicine DNA damage response gene therapy Catalysis Computer Science Applications leukocyte telomere length Inorganic Chemistry Huntington’s disease biomarker blood neurofilament light chain peripheral biomarker plasma Physical and Theoretical Chemistry Molecular Biology Spectroscopy |
| Zdroj: | International Journal of Molecular Sciences. 24:6051 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms24076051 |
| Popis: | Huntington’s disease (HD) is characterized by clinical motor impairment (e.g., involuntary movements, poor coordination, parkinsonism), cognitive deficits, and psychiatric symptoms. An inhered expansion of the CAG triplet in the huntingtin gene causing a pathogenic gain-of-function of the mutant huntingtin (mHTT) protein has been identified. In this review, we focus on known biomarkers (e.g., mHTT, neurofilament light chains) and on new biofluid biomarkers that can be quantified in plasma or peripheral blood mononuclear cells from mHTT carriers. Circulating biomarkers may fill current unmet needs in HD management: better stratification of patients amenable to etiologic treatment; the initiation of preventive treatment in premanifest HD; and the identification of peripheral pathogenic central nervous system cascades. |
| Databáze: | OpenAIRE |
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