BOLD-MRI for the assessment of renal oxygenation in humans: Acute effect of nephrotoxic xenobiotics
| Autor: | Felix J. Frey, Peter Vock, Chris Boesch, A. Nowak, Bruno Vogt, A. Giger, Lucie Hofmann, Sonja Simon-Zoula |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pathology
medicine.medical_specialty 030232 urology & nephrology BOLD-MRI Pharmacology 030218 nuclear medicine & medical imaging Nephrotoxicity 03 medical and health sciences 0302 clinical medicine non-steroidal anti-inflammatory drug indomethacin Renal medulla Medicine cyclosporine tacrolimus Medulla medicine.diagnostic_test business.industry Magnetic resonance imaging Oxygenation Hypoxia (medical) Tacrolimus 3. Good health Calcineurin iodinated radio-contrast media medicine.anatomical_structure Nephrology medicine.symptom business |
| Zdroj: | Kidney International. 70(1):144-150 |
| ISSN: | 0085-2538 |
| DOI: | 10.1038/sj.ki.5000418 |
| Popis: | Hypoxia of renal medulla is a key factor implicated in the development of drug-induced renal failure. Drugs are known to influence renal hemodynamics and, subsequently, affect renal tissue oxygenation. Changes in renal oxygenation can be assessed non-invasively in humans using blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI). This study was designed to test the acute effects of administration of specific drugs in healthy human kidney oxygenation using BOLD-MRI. Acute changes in renal tissue oxygenation induced by the non-steroidal anti-inflammatory drug indomethacin, the iodinated radio-contrast media (RCM) iopromidum, and the calcineurin inhibitors cyclosporine micro-emulsion (CsA-ME) and tracrolimus were studied in 30 healthy volunteers. A modified Multi Echo Data Image Combination sequence was used to acquire 12 T2*-weighted images. Four coronal slices were selected to cover both kidneys. The mean R2* (1/T2*) values determined in medulla and cortex showed no significant changes induced by indomethacin and tacrolimus administration. CsA-ME decreased medullary (P=0.008) and cortical (P=0.004) R2* values 2 h after ingestion. Iopromidum caused a significant increase in medullary R2* within the first 20 min after injection (P |
| Databáze: | OpenAIRE |
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