Immobilization stress-induced increment of lactate metabolism in the basolateral amygdaloid nucleus is attenuated by diazepam in the rat
| Autor: | Takashi Uehara, Tomiki Sumiyoshi, Masayoshi Kurachi, Kouichi Kurata |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Pharmacology medicine.medical_specialty Benzodiazepine Microdialysis Diazepam Chemistry GABAA receptor medicine.drug_class Stimulation Metabolism Amygdala Rats Immobilization Endocrinology Stress Physiological Flumazenil Internal medicine medicine Extracellular Animals Lactic Acid Rats Wistar medicine.drug |
| Zdroj: | European Journal of Pharmacology. 459:211-215 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/s0014-2999(02)02871-6 |
| Popis: | Using in vivo microdialysis technique, extracellular lactate levels were measured in the basolateral amygdaloid nucleus of the rat under immobilization stress. Immobilization stress (40 min) led to a tetrodotoxin-reversible increase in dialysate lactate levels. Diazepam (1.0 mg/kg, i.p.) reduced the ability of immobilization stress to increase lactate levels. Furthermore, the attenuation of the immobilization stress-induced increase of lactate levels by diazepam was antagonized by pretreatment with flumazenil (15 mg/kg, i.p.), a selective antagonist at benzodiazepine receptors. These findings suggest that immobilization stress increases lactate levels in rat basolateral amygdaloid nuclei, which is attenuated by stimulation of benzodiazepine receptors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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