Male androgenetic alopecia
| Autor: | Deepani Rathnayake, Rodney Sinclair |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Administration Topical Administration Oral Disease chemistry.chemical_compound 5 Alpha-Reductase Inhibitor Androgen Receptor Antagonists Medicine Humans Pharmacology (medical) Genetic Predisposition to Disease Hair transplantation Pharmacology Polymorphism Genetic integumentary system business.industry Finasteride Alopecia General Medicine Dutasteride medicine.disease Androgen Dermatology Combined Modality Therapy Hair loss chemistry Minoxidil Receptors Androgen Azasteroids business Men's Health medicine.drug Hair |
| Zdroj: | Expert opinion on pharmacotherapy. 11(8) |
| ISSN: | 1744-7666 |
| Popis: | IMPORTANCE OF THE FIELD: Androgenetic alopecia affects up to 80% of males by the age of 80. The synonym 'male-pattern hair loss' highlights the fact that hair loss occurs in a defined and reproducible pattern. Hair loss results in reduced self esteem, loss of confidence and anxiety in affected men. An effective treatment for hair baldness would be desirable. AREAS COVERED IN THIS REVIEW: In androgenetic alopecia, hair follicles undergo progressive miniaturization. Genetic factors and androgens play a major role in the pathogenesis of the disease. Polymorphism of the androgen receptor gene was first identified in association with androgenetic alopecia. Identification of new susceptibility genes on chromosomes 3q26 and 20p11 suggest that non-androgen-dependent pathways also are involved. WHAT THE READER WILL GAIN: Topical monoxidil and oral finasteride are commonly in use and have FDA approval for the treatment of male androgenetic alopecia; dutasteride, a type I and II 5-alpha-reductase inhibitor, is on hold in Phase III trials. A combination of medical treatment and hair transplant surgery has shown superior efficacy. TAKE-HOME MESSAGE: Androgenetic alopecia is a progressive condition and although the current available treatments are effective in arresting the progression of the disease, they allow only partial regrowth of hair at its best. Early treatment achieves the best desirable outcome. |
| Databáze: | OpenAIRE |
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