Trichomycins A and B: Antibacterial Triterpenes from the New Species Tricholoma sp. AU1
| Autor: | Gian Sberna, Jin Yu, Jill Bernays, Simon P. B. Ovenden, Dominique Lebeller, Larissa J. Christophidis, Soo San Wan, R. Murray Tait, Howard G. Wildman, Barbara M. Meurer-Grimes, Denis Platel, Tom W. May |
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| Rok vydání: | 2005 |
| Předmět: |
chemistry.chemical_classification
Pharmacology biology Chemistry Stereochemistry Tricholoma Organic Chemistry Pharmaceutical Science Pharmacognosy biology.organism_classification Terpenoid Analytical Chemistry Terpene Triterpene Complementary and alternative medicine Drug Discovery Molecular Medicine Antibacterial activity Two-dimensional nuclear magnetic resonance spectroscopy Antibacterial agent |
| Zdroj: | Journal of Natural Products. 68 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | To new triterpenes, trichomycins A (1) and B (2), were purified from the new species Tricholoma sp. AU1 by activity-guided fractionation following their antibacterial activity. The two compounds were found to have a hitherto unreported triterpenoid skeleton. The structures and relative stereochemistry of 1 and 2 were determined through extensive 2D NMR spectroscopy, while the inhibitory activity of 1 and 2 against two Gram-positive and two Gram-negative bacteria and a mammalian cell line was determined. |
| Databáze: | OpenAIRE |
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