Assisted reproductive technique in women of advanced fertility age
| Autor: | Maria Elena Rosa Obino, Paolo Giovanni Artini, Claudia Sergiampietri, Francesca Vergine, Francesca Papini, Vito Cela |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Infertility Aging Reproductive Techniques Assisted Reproductive techniques media_common.quotation_subject Fertility Ovary Fertilization in Vitro Assisted Obstetrics and Gynecology 03 medical and health sciences 0302 clinical medicine Human fertilization Obstetrics and gynaecology Androgen deficiency medicine Humans media_common 030219 obstetrics & reproductive medicine Reproductive Technique business.industry Reproduction medicine.disease Age and female fertility 030104 developmental biology medicine.anatomical_structure Oocytes Female business Infertility Female Demography Maternal Age |
| Popis: | Over the past four decades, the postponement of childbearing has continued to increase, significantly impacting the age of first-time mothers. Female age is the most significant factor influencing clinical outcome in in-vitro fertilization. To overcome the limits of the age-related decline of fertility is a challenge for fertility experts. In the decrease of fertility in late reproductive age, a lot of factors related with advancing women's age and general health can be considered, however the dominant regulator of this age-dependent loss of fertility is the ovary. The key factors in the ovarian aging are oxidative stress, abnormalities of the meiotic spindle, decrease of function and number of oocyte mitochondria, alteration of sirtuins and androgen deficiency. The aim of this review was to assess the main biological factors involved in the female reproductive ageing according to the recent literature, focusing on oocyte-dependent ones, as well as the possible therapeutic strategies in assisted reproductive technique. |
| Databáze: | OpenAIRE |
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