Fluconazole concentrations in pulmonary tissue and pericardial fluid
| Autor: | C. M. Rieder-Nelissen, R. A. Yeates, J. Hasse, E. Sarnow |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Microbiology (medical)
Antifungal Agents Metabolic Clearance Rate medicine.medical_treatment Triazole Biological Availability Pharmacology Pericardial Effusion chemistry.chemical_compound Pharmacokinetics Cricetinae medicine Animals Humans Pericardium Infusions Intravenous Fluconazole Lung Mycosis Chemotherapy business.industry Pericardial fluid General Medicine medicine.disease Infectious Diseases medicine.anatomical_structure chemistry Anesthesia business medicine.drug |
| Zdroj: | Infection. 25:192-194 |
| ISSN: | 1439-0973 0300-8126 |
| Popis: | In order to investigate the clinical efficacy of the triazole antifungal agent fluconazole (FCA) in the treatment of pulmonary mycosis, in the present study the concentrations of fluconazole in human pulmonary tissue, pericardial fluid and serum were determined at 1, 2, 12 and 13 h after intravenous administration of fluconazole 200 mg. The mean FCA concentrations in the serum were 4.04 mg/l (1 h), 3.82 mg/l (2 h), 2.35 mg/l (12 h) and 2.13 mg/l (13 h). The respective FCA levels in the pulmonary tissue were 4.64 mg/kg, 4.54 mg/kg; 3.50 mg/kg and 3.40 mg/kg and the concentrations in the pericardial fluid were 3.86 mg/l, 3.57 mg/l, 2.35 mg/l and 2.13 mg/l. The FCA concentrations in the pulmonary tissue that were statistically significant higher than the serum concentrations were found at 2 h, 12 h and 13 h after intravenous administration (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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