Induction of Fear Extinction with Hippocampal-Infralimbic BDNF
| Autor: | Laura M. Dieppa-Perea, Loyda M. Meléndez, Jamie Peters, Gregory J. Quirk |
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| Přispěvatelé: | Anatomy and neurosciences, NCA - Addictive Behavior, Neuroscience Campus Amsterdam - Addictive Behavior |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Prefrontal Cortex Hippocampus Hippocampal formation Receptors N-Methyl-D-Aspartate Piperazines Article Extinction Psychological Rats Sprague-Dawley Memory Conditioning Psychological Neural Pathways Animals Humans Medicine Fear conditioning Prefrontal cortex Fear processing in the brain Brain-derived neurotrophic factor Multidisciplinary business.industry Brain-Derived Neurotrophic Factor Fear social sciences Extinction (psychology) Recombinant Proteins humanities Rats nervous system Synaptic plasticity business Excitatory Amino Acid Antagonists Neuroscience |
| Zdroj: | Science, 328(5983), 1288-1290. American Association for the Advancement of Science Peters, J, Dieppa-Perea, L M, Melendez, L M & Quirk, G J 2010, ' Induction of Fear Extinction with Hippocampal-Infralimbic BDNF ', Science, vol. 328, no. 5983, pp. 1288-1290 . https://doi.org/10.1126/science.1186909 |
| ISSN: | 0036-8075 |
| DOI: | 10.1126/science.1186909 |
| Popis: | Pharmacological Forgetting Extinction of conditioned fear forms a new memory in the infralimbic medial prefrontal cortex that is critical for subsequent retrieval of the extinction memory. Understanding the mechanisms that underlie this extinction-related plasticity could help in the treatment of anxiety disorders. By infusing BDNF (brain-derived neurotrophic factor) into the infralimbic cortex, Peters et al. (p. 1288 ) caused the extinction of conditioned fear, even without an extinction trial. In fact, BDNF infusion seemed to act as if an extinction training session had been given. Thus, the hippocampus is a likely source of the BDNF input to the infralimbic cortex, and individual differences in extinction memory may reflect variations in hippocampal BDNF content. |
| Databáze: | OpenAIRE |
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