Sequential Acral Lentiginous Melanomas of the Foot
| Autor: | Ichiro Takahashi, Akemi Ishida-Yamamoto, Yasuhiro Ito, Jiro Uehara, Masaru Honma, Hajime Iizuka, Shinobu Matsuo |
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| Rok vydání: | 2010 |
| Předmět: |
Pathology
medicine.medical_specialty Surgical margin Acral lentiginous melanoma Dermatology Lesion Melanoma spread lcsh:Dermatology medicine Cyclin D1 Subclinical infection Surgical margins business.industry Melanoma lcsh:RL1-803 medicine.disease Primary melanoma Published: December 2010 Field cell model Surgical excision medicine.symptom Wound healing business Foot (unit) |
| Zdroj: | Case Reports in Dermatology, Vol 2, Iss 3, Pp 201-206 (2010) Case Reports in Dermatology |
| ISSN: | 1662-6567 |
| DOI: | 10.1159/000323467 |
| Popis: | A 64-year-old Japanese woman had a lightly brown-blackish pigmented macule (1.2 cm in diameter) on the left sole of her foot. She received surgical excision following a diagnosis of acral lentiginous melanoma (ALM), which was confirmed histopathologically. One month after the operation, a second melanoma lesion was noticed adjacent to the grafted site. Histopathologically, the two lesions had no continuity, but HMB-45 and cyclin D(1) double-positive cells were detected not only on aggregates of atypical melanocytes but also on single cells near the cutting edge of the first lesion. The unique occurrence of a sequential lesion of a primary melanoma might be caused by stimulated subclinical field cells during the wound healing process following the initial operation. This case warrants further investigation to establish the appropriate surgical margin of ALM lesions. |
| Databáze: | OpenAIRE |
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