Assay for antiviral activity of herbal extracts using their absorbed sera
| Autor: | Michio Nakano, Tsuneo Namba, Kimiyasu Shiraki, Masahiko Kurokawa, Haruo Ohyama, Toyoharu Hozumi |
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| Rok vydání: | 1996 |
| Předmět: |
Guinea Pigs
Drug Evaluation Preclinical Herpesvirus 1 Human Pharmacognosy Pharmacology medicine.disease_cause Virus Replication Antiviral Agents Herpesviridae Virus Guinea pig In vivo Alphaherpesvirinae Drug Discovery Chlorocebus aethiops medicine Animals Vero Cells biology Chemistry Plant Extracts Biological activity General Chemistry General Medicine biology.organism_classification Virology Herpes simplex virus Female |
| Zdroj: | Chemicalpharmaceutical bulletin. 44(6) |
| ISSN: | 0009-2363 |
| Popis: | We evaluated an antiviral assay procedure using serum obtained from guinea pigs administered 32 herbal extracts. In this assay, 21 of the 32 showed anti-herpes simplex virus type 1 (HSV-1) activity in serum. Ten of the 21 exhibited therapeutic anti-HSV-1 activity, and this was consistent with our previous results that 12 of the 32 were effective in murine infection models. Therefore, the serum pharmacological assay procedure was suitable for the selection of possible herbal extracts with biological activity in vivo as a pre-screening method before animal experiments. |
| Databáze: | OpenAIRE |
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