Aconite induced myelo-optic neuropathy in a rabbit model
| Autor: | Jae Pil Shin, Kui Duk Suk, Kyung Cheol Yoon, Sang Ha Kim |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pathology
medicine.medical_specialty genetic structures Optic neuropathy Optic Nerve Diseases Medicine Animals Evoked potential Myelin Sheath Aconitum business.industry Alkaloid Optic Nerve General Medicine Anatomy Spinal cord medicine.disease eye diseases medicine.anatomical_structure Spinal Cord Myelin sheath Visual Disturbance Rabbit model Evoked Potentials Visual Rabbits business Injections Intraperitoneal |
| Zdroj: | Korean journal of ophthalmology : KJO. 8(2) |
| ISSN: | 1011-8942 |
| Popis: | Aconite is a common remedy of herb doctors and is widely used in the Far East. Clinical aspects of the visual disturbance produced by this drug have been described, but little is known about its pathology. Tinctura aconiti (0.6 mg of total alkaloid/kg 2x) was administered intraperitoneally in rabbits to evaluate its toxic effects on the visual system. The alteration in the visual evoked potential following aconite injection consisted of a delay in the onset and peak latency. Histopathologically, there were damages to the myelin sheath of the visual pathway, spinal cord and peripheral nerves. These findings suggest that aconite may cause primarily myelo-optic neuropathy. |
| Databáze: | OpenAIRE |
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