Development of a continuous reactor for emulsion-based microencapsulation of hexyl acetate with a polyuria shell

Autor: Roberto F. A. Teixeira, Simon Kuhn, Marleen Segers, Sven R. L. Gobert, Stijn Luca, Leen C.J. Thomassen, Leen Braeken
Rok vydání: 2019
Předmět:
Technology
LIQUID-LIQUID DISPERSION
FLOW
Pharmaceutical Science
02 engineering and technology
Acetates
030226 pharmacology & pharmacy
energy dissipation rate
law.invention
HYDRODYNAMICS
chemistry.chemical_compound
Engineering
0302 clinical medicine
Colloid and Surface Chemistry
law
Hexyl acetate
Pharmacology & Pharmacy
BREAKAGE
static mixer
STATIC MIXERS
Equipment Design
DROPLET FORMATION
021001 nanoscience & nanotechnology
Residence time distribution
Chemistry
Applied
Chemistry
recirculation loop
Physical Sciences
Emulsion
MICROCHANNEL
Emulsions
0210 nano-technology
Life Sciences & Biomedicine
Engineering
Chemical
Materials science
Drug Compounding
Shell (structure)
Bioengineering
Capsules
Static mixer
03 medical and health sciences
Physical and Theoretical Chemistry
Particle Size
Microencapsulation
FORMULATION
Science & Technology
Continuous reactor
Organic Chemistry
RESIDENCE TIME DISTRIBUTION
flow reactor
chemistry
Chemical engineering
MEMBRANE
Zdroj: Journal of microencapsulation. 36(4)
ISSN: 1464-5246
Popis: Microencapsulation is almost exclusively performed in batch processes. With today's chemistry increasingly performed in flow reactors, this work aims to realise a continuous reactor setup for the encapsulation of an ester with a polyuria (PU) shell. The generation of an emulsion template is performed in a recirculation loop driven by a pump and equipped with static mixers, screen type and Kenics®. Calorimetric measurements are performed to characterise the energy dissipation rate inside the loop. The curing step is performed in a coiled tube reactor with two geometric configurations. Number based capsule size distributions are derived from micrograph analysis. Results indicate that the recycle pump is the main contributor to determine the capsule size distribution. A continuous setup is achieved for PU microcapsules containing hexyl acetate with a production rate of 198 g/h dry capsules, and a mean capsule diameter of 13.3 µm with a core content of 54 wt%. ispartof: JOURNAL OF MICROENCAPSULATION vol:36 issue:4 pages:371-384 ispartof: location:England status: published
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje