Mitochondrial DNA Variations in Russian and Belorussian Populations
| Autor: | Marina Bermisheva, Andrey Khrunin, Olga V. Belyaeva, Elza Khusnutdinova, A. I. Mikulich, Petr Slominsky, N. A. Bebyakova, Svetlana A. Limborska |
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| Rok vydání: | 2003 |
| Předmět: |
Genetics
Mitochondrial DNA Polymorphism Genetic Republic of Belarus Phylogenetic tree Haplotype Genetic Variation Cell Cycle Proteins Biology DNA Mitochondrial Haplogroup Russia Eastern european Epidemiologic Studies Genetics Population Haplotypes Polymorphism (computer science) Humans Schizosaccharomyces pombe Proteins Polymorphism Restriction Fragment Length Genetics (clinical) Ecology Evolution Behavior and Systematics |
| Zdroj: | Human Biology. 75:647-660 |
| ISSN: | 1534-6617 |
| Popis: | 1 Abstract The sequence of the first hypervariable segment (HVS-I) of mi- tochondrial DNA (mtDNA) was determined in 251 individuals from three eastern Slavonic populations, two Russian and one Belorussian. Within HVS-I, 78 polymorphic positions were revealed. Within-population diversity of HVS-I varies slightly among three samples; its estimates do not differ strongly from those for European populations. Haplotype diversity for three populations calculated in this study is 0.949; mean pairwise differences esti- mate is 3.59. To assign mtDNA sequences to major phylogenetic clusters, haplogroup-specific restriction polymorphisms were selectively typed in most samples. The haplogroup distribution in the total Eastern Slavonic sam- ple is similar to that reported for the European sample. However, the separate consideration of three Slavonic samples reveals the complicated structure of the mitochondrial gene pool in the Eastern European area. Data of this study support the proposed model of the origin of modern Eastern Slavs, which im- plies the admixture of ancient Slavonic tribes with pre-Slavonic populations of Eastern Europe. These data should contribute to general studies of mito- chondrial DNA variations in Europe. |
| Databáze: | OpenAIRE |
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