Spectral and lifetime domain measurements of rat brain tumours
| Autor: | Geneviève Bourg-Heckly, N. Sandeau, Imène Chebbi, D. Abi Haidar, K. Allaoua, Christine Vever-Bizet, Marie Steffenhagen, B. Leh, Donald A. Peyrot, A. Genoux, M. Collado-Hilly, Rainer Siebert |
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| Přispěvatelé: | Imagerie et Modélisation en Neurobiologie et Cancérologie (IMNC (UMR_8165)), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Métrologie et de Dosimétrie des Neutrons (IRSN/PRP-HOM/SDE/LMDN), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Laboratoire Jean PERRIN, Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Institut FRESNEL (FRESNEL), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), SPIE, Laboratoire de Métrologie et de Dosimétrie des Neutrons (LMDN), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU) |
| Rok vydání: | 2012 |
| Předmět: |
[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics]
0303 health sciences Chemistry business.industry Normal tissue medicine.disease Rat brain 01 natural sciences Fluorescence Fluorescence spectroscopy 010309 optics 03 medical and health sciences Tumour tissue Nuclear magnetic resonance Optics Two-photon excitation microscopy 0103 physical sciences medicine business 030304 developmental biology Tissue fluorescence Glioblastoma |
| Zdroj: | Photonic Therapeutics and Diagnostics VIII Spectral and lifetime domain measurements of rat brain tumours Spectral and lifetime domain measurements of rat brain tumours, Jan 2012, San Jose, United States. pp.82074P, ⟨10.1117/12.907411⟩ |
| ISSN: | 0277-786X |
| DOI: | 10.1117/12.907411 |
| Popis: | International audience; During glioblastoma surgery, delineation of the brain tumour margins remains difficult especially since infiltrated and normal tissues have the same visual appearance. This problematic constitutes our research interest. We developed a fibre-optical fluorescence probe for spectroscopic and time domain measurements. First measurements of endogenous tissue fluorescence were performed on fresh and fixed rat tumour brain slices. Spectral characteristics, fluorescence redox ratios and fluorescence lifetime measurements were analysed. Fluorescence information collected from both, lifetime and spectroscopic experiments, appeared promising for tumour tissue discrimination. Two photon measurements were performed on the same fixed tissue. Different wavelengths are used to acquire two-photon excitation-fluorescence of tumorous and healthy sites. |
| Databáze: | OpenAIRE |
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