Dehydroepiandrosterone sulfate/free androgen index ratio predicts a favorable metabolic profile in patients with polycystic ovary syndrome
| Autor: | Kadriye Aydin, Aysenur Ozderya, Osman Temizkan, Ekrem Orbay, Ahmet Nadir, Sule Temizkan |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Body Mass Index 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Endocrinology Insulin resistance Dehydroepiandrosterone sulfate Internal medicine medicine Humans Insulin Triglycerides 030219 obstetrics & reproductive medicine business.industry Free androgen index Dehydroepiandrosterone Sulfate Polycystic ovary syndrome (PCOS) Cholesterol HDL Area under the curve nutritional and metabolic diseases Obstetrics and Gynecology Fasting medicine.disease Polycystic ovary Logistic Models chemistry Case-Control Studies Androgens Female Insulin Resistance business Body mass index Polycystic Ovary Syndrome |
| Zdroj: | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 35(2) |
| ISSN: | 1473-0766 |
| Popis: | Potential effect of hyperandrogenemia on metabolic disturbances in polycystic ovary syndrome (PCOS) has always been a matter of interest. We analyzed the records of 125 patients with PCOS and 54 age-matched healthy women. All participants underwent biochemical and hormonal assessment and a 75 g oral glucose tolerance test was performed. PCOS and control groups were comparable in terms of age. Dehydroepiandrosterone sulfate/free androgen index (DHEAS/FAI) ratio was negatively correlated with body mass index (BMI) (p < .001), fasting glucose (p = .02), area under the curve (AUC) of glucose (p = .03), AUC of insulin (p = .001), homeostasis model assessment-estimated insulin resistance (HOMA-IR) (p < .001), and triglycerides (TG) (p = .009), and positively correlated with insulin sensitivity index (ISI) (p < .001) and high-density lipoprotein cholesterol (HDL-C) (p < .001) among PCOS patients. In logistic regression analysis, higher DHEAS/FAI ratio levels were associated with lower risk of low HDL-C [RR(95%CI); 0.97(0.95-0.98); p < .001] as well as atherogenic dyslipidemia (TG/HDL-C) [RR(95%CI); 0.97(0.94-0.99); p = .035] even after adjustment for BMI in the PCOS group. Androgens, DHEAS and FAI act differently on metabolic parameters. Our results demonstrate that high DHEA-S/FAI ratio levels are associated with a more favorable metabolic profile. |
| Databáze: | OpenAIRE |
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