Determining Real Change in Conditioned Pain Modulation: A Repeated Measures Study in Healthy Volunteers
| Autor: | Andrew S.C. Rice, Donna Kennedy, Harriet I. Kemp, Chenxian Wu, Deborah Ridout |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pain Threshold medicine.medical_specialty Stimulus (physiology) Audiology Nociceptive Pain Young Adult 03 medical and health sciences 0302 clinical medicine Cohen's kappa 030202 anesthesiology Reliability study parasitic diseases Healthy volunteers Humans Medicine Contact heat Pain Measurement business.industry Reproducibility of Results Repeated measures design Middle Aged Healthy Volunteers Anesthesiology and Pain Medicine Standard error Neurology Conditioned pain modulation embryonic structures Female Neurology (clinical) business human activities 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Pain. 21:708-721 |
| ISSN: | 1526-5900 |
| Popis: | Conditioned pain modulation (CPM) is a potentially useful biomarker in pain populations; however, a statistically robust interpretation of change scores is required. Currently, reporting of CPM does not consider measurement error. Hence, the magnitude of change representing a “true” CPM effect is unknown. This study determined the standard error of measurement (SEM) and proportion of healthy participants showing a “true” CPM effect with a standard CPM paradigm. Fifty healthy volunteers participated in an intersession reliability study using pressure pain threshold (PPT) test stimulus and contact heat, cold water, and sham conditioning stimuli. Baseline PPTs were used to calculate SEM and >±2 × SEM to determine CPM effect. SEM for PPT was .21 kg/cm2. An inhibitory CPM effect (>+2 SEM) was elicited in 59% of subjects in response to cold stimulus; in 44% to heat. Intrasession and intersession reliability of within-subject CPM response was poor (kappa coefficient Perspective This study used a distribution-based statistical approach to identify real change in CPM, based on the SEM for the test stimulus. Healthy volunteers demonstrate substantial within-subject variation; CPM effect was paradigm dependent at intrasession testing and unstable to the same paradigm at intersession testing. |
| Databáze: | OpenAIRE |
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