The levels of sICAM-1, sELAM-1, TNFα and sTNFR1 proteins in patients with colorectal adenocarcinoma in tumor and corresponding normal mucosa
| Autor: | Benjamin Bochon, Aleksander Owczarek, Łukasz Krakowczyk, Zofia Ostrowska, Krzysztof Gajdzik, Joanna Katarzyna Strzelczyk, Andrzej Wiczkowski, Piotr Cuber, Janusz Strzelczyk |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Colorectal cancer Gene Expression Disease Adenocarcinoma Gastroenterology General Biochemistry Genetics and Molecular Biology Internal medicine Biomarkers Tumor Medicine Humans In patient Colorectal adenocarcinoma Stage (cooking) Intestinal Mucosa Aged Aged 80 and over Gastrointestinal tract business.industry Tumor Necrosis Factor-alpha Cancer Middle Aged medicine.disease Intercellular Adhesion Molecule-1 Survival Analysis Receptors Tumor Necrosis Factor Type I Lymphatic Metastasis Tumor necrosis factor alpha Female business Colorectal Neoplasms E-Selectin |
| Zdroj: | Acta biochimica Polonica. 67(4) |
| ISSN: | 1734-154X |
| Popis: | Colorectal cancer is a common malign disease of the gastrointestinal tract. The cancer survival rate depends on the stage of the disease at detection time. It is well known that several molecular mechanisms are involved in cancer and some molecules might affect or modulate neogenesis. The aim of the study was to assess the levels of sICAM-1, sELAM-1, TNFα and sTNFR1 protein in tumor and corresponding normal mucosa in a group of patients with colorectal adenocarcinoma and also associations of these parameters with demographic and clinical profiles of the patients. Tissue specimens were obtained during resection of neoplastic lesions. Protein levels were assayed in tissue homogenates by ELISA. The protein level of sICAM-1 in tumor was significantly increased in comparison to the corresponding normal mucosa (80.06 ng/mg vs 69.53 ng/mg, p=0.02). Furthermore, a significant positive correlation between sICAM-1 and sTNFR1 proteins levels in tumor (rs=0.58, p |
| Databáze: | OpenAIRE |
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