Discovery of Pyrano[3,4-b]indoles as Potent and Selective HCV NS5B Polymerase Inhibitors

Autor:	Gregory Ciszewski, John W. Ellingboe, Yelena Pyatski, Ariamala Gopalsamy, Tarek S. Mansour, Kaapjoo Park, Girija Krishnamurthy, Anita Y. M. Howe, Murthy Damarla, Janis Upeslacis, Douglas M. Ho, Boris Feld, Bloom Jonathan David, Kitae Lim, John O'Connell, Mark Orlowski, Shabana Insaf
Rok vydání:	2004
Předmět:	Indoles viruses Hepatitis C virus Hepacivirus Viral Nonstructural Proteins Crystallography X-Ray medicine.disease_cause Antiviral Agents Structure-Activity Relationship chemistry.chemical_compound RNA polymerase Drug Discovery medicine Replicon NS5B Pyrans Indole test chemistry.chemical_classification virus diseases Stereoisomerism DNA-Directed RNA Polymerases biochemical phenomena metabolism and nutrition Nucleotidyltransferase digestive system diseases In vitro Enzyme chemistry Biochemistry Molecular Medicine
Zdroj:	Journal of Medicinal Chemistry. 47:6603-6608
ISSN:	1520-4804 0022-2623
DOI:	10.1021/jm0401255
Popis:	A novel series of HCV NS5B RNA-dependent RNA polymerase inhibitors containing a pyrano[3,4-b]indole scaffold is described leading to the discovery of compound 16, a highly potent and selective inhibitor that is active in the replicon system.
Databáze:	OpenAIRE
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