LGR4 cooperates with PrPc to endow the stemness of colorectal cancer stem cells contributing to tumorigenesis and liver metastasis

Autor:	Qi Cheng, Hao Zheng, Ming Li, Hongyi Wang, Xiaoxiao Guo, Zhibo Zheng, Chuyan Chen, Jinming Liu, Tiancheng Zhan, Zhaowei Li, Hao Wu, Jingdong Han, Lei Liu, Tieshan Tang, Quan Chen, Lei Du
Rok vydání:	2022
Předmět:	Cancer Research Cell Transformation Neoplastic Oncology Carcinogenesis Cell Line Tumor Liver Neoplasms Neoplastic Stem Cells Humans Colorectal Neoplasms Wnt Signaling Pathway Receptors G-Protein-Coupled
Zdroj:	Cancer letters. 540
ISSN:	1872-7980
Popis:	Cancer stem cells (CSCs) are a subpopulation of cancer cells that drive tumour progression and metastasis. Anti-CSC strategies represent new targets for cancer therapies. However, CSCs are highly plastic and heterogeneous, making validation and targeting difficult without bona fide markers that define their identity, especially in a clinical setting. Here, we report that a leucine-rich repeat containing G protein-coupled receptor 4 (LGR4) cooperates with CD44 and PrPc; the latter contributes significantly to metastatic capacity and defines the stemness characteristics of colorectal CSCs. CD44
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c51de75f30df0e622814f23872f4702 https://pubmed.ncbi.nlm.nih.gov/35561877 Zobrazit plný text záznamu Full Text from ScienceDirect