Fractional excretion as a new marker of tubular damage in children with chronic kidney disease
| Autor: | Kinga Musiał, Danuta Zwolińska |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Vitamin medicine.medical_specialty Adolescent Clinical Biochemistry 030232 urology & nephrology Urology Renal function Enzyme-Linked Immunosorbent Assay Urine urologic and male genital diseases Biochemistry Excretion 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Heat Shock Transcription Factors medicine Humans Renal Insufficiency Chronic Child business.industry Biochemistry (medical) General Medicine Serum concentration medicine.disease Kidney Tubules 030104 developmental biology chemistry Child Preschool Female Creatinine urine Creatinine.serum business Retinol-Binding Proteins Plasma Biomarkers Glomerular Filtration Rate Kidney disease |
| Zdroj: | Clinica Chimica Acta. 480:99-106 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2018.02.001 |
| Popis: | Objectives Vitamin D-binding protein (VDBP), retinol-binding protein (RBP)4, and heat shock proteins (hsp) are markers of tubular function and apoptosis, accompanying chronic kidney disease (CKD) from its earliest stages. Fractional excretion of proteins with urine is a marker of tubular damage. The aim of study was to assess the usefulness of fractional excretion (FE) of VDBP, RBP4, HSF1 and Hsp27 as markers of tubular damage in the course of CKD. Methods The study group consisted of 70 children with CKD stages 1–5, treated conservatively, and 12 age-matched controls with normal kidney function. The serum and urine concentrations of VDBP, RBP4, HSF1 and Hsp27 were assessed by ELISA. The fractional excretion of analyzed parameters was calculated according to the formula: ([parameter urine concentration] × [creatinine serum concentration]) / ([parameter serum concentration] × [creatinine urine concentration])×100%. Results The FE values of all parameters exceeded 1% in CKD stage 2. However, the values of FE have raised significantly versus control group no sooner than CKD stage 2 (RBP4 and HSF1), stage 3 (VDBP) or stage 4 (Hsp27). Conclusion Fractional excretion of RBP4 and HSF1 with urine may become a valuable marker, assessing the damage of tubular cells in children with CKD. |
| Databáze: | OpenAIRE |
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